CARD R-BASE



Mouse strain


Strain information

CARD ID 3461
Type of strain Transgenic., Targeted mutant.
Strain name B6D2-Pdha2em1OsbTg(Clgn-Pdha1/PA/1D4)1Osb
Internal Code Pdha2 KO+Tg
Submitter Ikawa Masahito
Submitter affiliation or code Animal Resource Center for Infectious Diseases Research Institute for Microbial Diseases Osaka University
Stock Type
Material Transfer Conditions Others
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again.
Production method in-house breeding
Origin (In-house) Organization Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University
Organization code
Developer Masahito Ikawa
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Pdha2
Gene name pyruvate dehydrogenase E1 alpha 2
Allele symbol Pdha2em1Osb
Allele name pyruvate dehydrogenase E1 alpha 2; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI MGI:97533,
Chromosome
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM
Gene symbol Pdha1
Gene name pyruvate dehydrogenase E1 alpha 1
Allele symbol Tg(Clgn-Pdha1/PA/1D4)1Osb
Allele name
MGI MGI:97532,
Chromosome
Gene classification Gene to express(transgenic)
Method MicroInjection
OMIM



References

Author Chen Pan, Keisuke Shimada , Hsin-Yi Chang, Haoting Wang, Masahito Ikawa
Title Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis
Journal Development .
Volume
Page
Year 2025
PMID 40679056


Disease , Applicable field information

Disease name, Applicable field






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