| CARD ID | 293 | |
| Type of strain | Targeted mutant. | |
| Strain name | B6;129-Mdktm1 | |
| Internal Code | MK knockout mouse, MK knockout mouse (C57BL6J/129SV) | |
| Submitter | Unknown Unknown | |
| Submitter affiliation or code | ||
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
|
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| Production method | in-house breeding | |
| Origin (In-house) | Organization | Department of Biochemistry, Nagoya University, Graduate School of Medicine |
| Organization code | ||
| Developer | Takashi Muramatsu | |
| Origin (From other organizations) | Organization | |
| Organization code | ||
| Developer | ||
| Year introduced | ||
| Introduced Generation | ||
| Remarks | ||
| Gene symbol | Mdk |
| Gene name | Midkine |
| Allele symbol | Mdktm1 |
| Allele name | Mdk, targeted mutation 1 |
| MGI | MGI:96949, |
| Chromosome | 2 (53.0cM) , |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | |
| GO | Gene Ontology |
| OMIM | OMIM ID: 162096 Human Gene Symbol: MDK, |
| primerA | 5'(TAACC,CAggT,TTTAC,CCCTA)3' |
| primerB | 5'(CTCCA,AATTC,CTTCC,TTCTT,CCAg)3' |
| Author | Mitsuru Horiba, Kenji Kadomatsu, Eishin Nakamura, Hisako Muramatsu, Shinya Ikematsu, Sadatoshi Sakuma, Kenji Hayashi, Yukio Yuzawa, Seiichi Matsuo, Masafumi Kuzuya, Tadashi Kaname, Makoto Hirai, Hidehiko Saito, and Takashi Muramatsu |
| Title | Neointima formation in a restenosis model is suppressed in midkine-deficient mice |
| Journal | The Journal of Clinical Investigation |
| Volume | 105 |
| Page | 489-495 |
| Year | 2000 |
| PMID | 10683378 |
| Author | Eishin Nakamura, Kenji Kadomatsu, Shigeki Yuasa, Hisako Muramatsu, Takayoshi Mamiya, Toshitaka Nabeshima, Qi-Wen Fan, Kazuhiro Ishiguro, Tadahiko Igakura, Shuichiro Matsubara, Tadashi Kaname, Mitsuru Horiba, Hidehiko Saito and Takashi Muramatsu |
| Title | Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour |
| Journal | Genes to Cells |
| Volume | 3 |
| Page | 811-822 |
| Year | 1998 |
| PMID | 10096022 |
| Author | Waichi Sato, Kenji Kadomatsu, Yukio Yuzawa, Hisako Muramatsu, Nigishi Hotta, Seiichi Matsuo, and Takashi Muramatsu |
| Title | Midkine Is Involved in Neutrophil Infiltration into the Tubulointerstitium in Ischemic Renal Injury |
| Journal | The Journal of Immunology |
| Volume | 167 |
| Page | 3463-3469 |
| Year | 2001 |
| PMID | 11544339 |
| Disease name, Applicable field | Development |