| CARD ID | 2104 | |
| Type of strain | Transgenic., Targeted mutant. | |
| Strain name | B6;129-Pccatm1ToruTg(SAP-Pcca)47Toru | |
| Internal Code | PCCA KO/ PCCA TG | |
| Submitter | Miyazaki Toru | |
| Submitter affiliation or code | Lab of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine (CDBIM), The University of Tokyo | |
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
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| Production method | in-house breeding | |
| Origin (In-house) | Organization | |
| Organization code | ||
| Developer | ||
| Origin (From other organizations) | Organization | |
| Organization code | ||
| Developer | ||
| Year introduced | ||
| Introduced Generation | ||
| Remarks | ||
| Gene symbol | Pcca |
| Gene name | propionyl-Coenzyme A carboxylase, alpha polypeptide |
| Allele symbol | tg(SAP-Pcca) |
| Allele name | |
| MGI | MGI:97499, |
| Chromosome | |
| Gene classification | Gene to express(transgenic) |
| Method | MicroInjection |
| OMIM |
| Gene symbol | Pcca |
| Gene name | propionyl-Coenzyme A carboxylase, alpha polypeptide |
| Allele symbol | Pccatm1Timy |
| Allele name | propionyl-Coenzyme A carboxylase, alpha polypeptide, targeted mutation 1, Toru Miyazaki |
| MGI | MGI:97499, |
| Chromosome | 14 (65.99) (14E5) , |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | Electroporation |
| OMIM |
| beta-globin 5 | TGC TGG TTA TTG TGC TGT CTC ATC |
| PCCA 300R | AAT GGC AAC TGT CTT GAT GCC CAT |
| RV13 | GTA TCC ATC ATG GCT GAT GCA A |
| RV14 | AAC GCT ATG TCC TGA TAG CGG T |
| Author | Miyazaki T, Ohura T, Kobayashi M, Shigematsu Y, Yamaguchi S, Suzuki Y, Hata I, Aoki Y, Yang X, Minjares C, Haruta I, Uto H, Ito Y, Müller U |
| Title | Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase and its rescue by postnatal, liver-specific supplementation via a transgene. |
| Journal | J Biol Chem |
| Volume | 276 |
| Page | 35995-9 |
| Year | 2001 |
| PMID |
| Disease name, Applicable field | Metabolism |