| CARD ID | 1524 | |
| Type of strain | Transgenic. | |
| Strain name | BKS.NOD-Tg(hIns-TRX)90Miya | |
| Internal Code | Ins-TRX mouse | |
| Submitter | Miyazaki Jun-ichi | |
| Submitter affiliation or code | Division of Stem Cell Regulation Research,Osaka University Graduate School of Medicine | |
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
|
|
| Production method | in-house breeding | |
| Origin (In-house) | Organization | Osaka University Graduate School of Medicine |
| Organization code | Miya | |
| Developer | Jun-ichi Miyazaki | |
| Origin (From other organizations) | Organization | |
| Organization code | ||
| Developer | ||
| Year introduced | ||
| Introduced Generation | ||
| Remarks | ||
| Gene symbol | TRX |
| Gene name | Thioredoxin |
| Allele symbol | Tg(hIns-TRX)90Miya |
| Allele name | transgene insertion 90 Jun-ichi Miyazaki |
| MGI | |
| Chromosome | |
| Gene classification | Gene to express(transgenic) |
| Method | MicroInjection |
| OMIM |
| BG-S0 | 5'-gCtggTTATTgTgCTgTCTC-3' |
| hTRX-A1 | 5'-TCATCCACATCTACTTCAAggA-3' |
| Author | Mizuo Hotta, Fumi Tashiro, Hiroshi Ikegami, Hitoshi Niwa, Toshio Ogihara, Junji Yodoi, and Jun-ichi Miyazaki |
| Title | Pancreatic beta Cell–specific Expression of Thioredoxin, an Antioxidative and Antiapoptotic Protein, Prevents Autoimmune and Streptozotocin-induced Diabetes |
| Journal | J.Exp.Med |
| Volume | 188 |
| Page | 1445-1451 |
| Year | 1998 |
| PMID |
| Author | Mayu Yamamoto, Eiji Yamato, Toyoda Shu-Ichi, Fumi Tashiro, Hiroshi Ikegami, Junji Yodoi, Jun-Ichi Miyazaki |
| Title | Transgenic Expression of Antioxidant Protein Thioredoxin in Pancreatic beta Cells Prevents Progression of Type 2 Diabetes Mellitus |
| Journal | Antioxidants & Redox Signaling |
| Volume | 10 |
| Page | 43-50 |
| Year | 2008 |
| PMID |
| Disease name, Applicable field | Metabolism |