CARD ID | 2292 | |
Type of strain | Targeted mutant. | |
Strain name | B6;129S-Hmgcrtm1Ishi | |
Internal Code | floxHMGCRKO | |
Submitter | ISHIBASHI SHUN | |
Submitter affiliation or code | Jichi Medical University | |
Stock Type | ||
Material Transfer Conditions |
Others
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Production method | in-house breeding | |
Origin (In-house) | Organization | |
Organization code | Ishi | |
Developer | Shun Ishibashi | |
Origin (From other organizations) | Organization | |
Organization code | ||
Developer | ||
Year introduced | ||
Introduced Generation | ||
Remarks |
Gene symbol | Hmgcr |
Gene name | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
Allele symbol | Hmgcrtm1Ishi |
Allele name | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; targeted mutation 1, Shun Ishibashi |
MGI | MGI:96159, |
Chromosome | 13 (50.65) , |
Gene classification | Targeted or trapped gene(knockout etc.) |
Method | |
OMIM |
lox4 | 5'-GTC GAC GTT GAA TCC TCT TGT CAG AC-3' |
xho3' | 5'-CAA AGC AGA CAT GAG ACT ATT C-3' |
Author | Shuichi Nagashima |
Title | Liver-Specific Deletion of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Causes Hepatic Steatosis and Death |
Journal | Arterioscler Thromb Vasc Biol. |
Volume | 32 (8) |
Page | 1824-1831 |
Year | 2012 |
PMID |
Disease name, Applicable field |