CARD R-BASE



Mouse strain


Strain information

CARD ID 527
Type of strain Targeted mutant.
Strain name B6.129-Kcnj8tm1Kusm
Internal Code Kir6.1 deficient mouse, B6.129-Kcnj8tm1Kusm
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Others
Production method in-house breeding
Origin (In-house) Organization Div Cell & Mol Med, Kobe Univ Grad Sch Med
Organization code Kusm
Developer Susumu Seino
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Kcnj8 (Synonym:Kir6.1)
Gene name potassium inwardly-rectifying channel, subfamily J, member 8
Allele symbol Kcnj8tm1Kusm
Allele name targeted mutation 1, Division of Cellular and Molecular Medicine, Kobe University School of Medicine
MGI
Chromosome 6 (70.0 cM) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM OMIM ID: 600935 Human Gene Symbol: KCNJ8,

PCR Primer 1
Kir6.1-KO-3fw 5'-AAT GGC CGA TCC CAT ATT GG-3'
Kir6.1-KO-2rc 5'-CTG AAC TGG TGA TGA GTG CA-3'


References

Author TAKASHI MIKI, MASASHI SUZUKI, TADAO SHIBASAKI, HIROKO UEMURA, TOSHIAKI SATO, KAORI YAMAGUCHI, HARUHIKO KOSEKI, TOSHIHIKO IWANAGA, HARUAKI NAKAYA & SUSUMU SEINO
Title Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Journal NATURE MEDICINE
Volume 8
Page 466-472
Year 2002
PMID 11984590


Disease , Applicable field information

Disease name, Applicable field Neurobiology, Physiology






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