| CARD ID | 365 | |
| Type of strain | Targeted mutant. | |
| Strain name | B6;129X1-Adra1btm1 | |
| Internal Code | B6/129sv-α1BD-AR-KO | |
| Submitter | Nakamura Kazuaki | |
| Submitter affiliation or code | National Research Institute for Child Health and Development | |
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
|
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| Production method | in-house breeding | |
| Origin (In-house) | Organization | |
| Organization code | unknown | |
| Developer | Tanoue Akito | |
| Origin (From other organizations) | Organization | |
| Organization code | ||
| Developer | ||
| Year introduced | ||
| Introduced Generation | ||
| Remarks | ||
| Gene symbol | Adra1b |
| Gene name | Adrenergic receptor, alpha 1b |
| Allele symbol | Adra1btm1 |
| Allele name | Adra1b, targeted mutation 1 |
| MGI | MGI:104774, |
| Chromosome | 11 , |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | Electroporation |
| GO | Gene Ontology |
| OMIM | OMIM ID: 104220 Human Gene Symbol: ADRA1B, |
| primerA | 2.C alpha1D: (1)PCR primer A 5'(ACACA,GCTGC,ACTCA,GTAGC,AGGTC,A)3' alpha1B: (1)PCR primer A 5'(CCTGC,AGGTA,TGAGG,CTCTG,T)3' |
| primerB | 2.C alpha1D: (2)PCR primer B 5'(CCTAC,ATTTT,GAATG,GAAGG,ATTG)3' alpha1B: (2)PCR primer B 5'(ATTTG,TCACG,TCCTG,CACGA,C)3' |
| Author | ANTONELLA CAVALLI, ANNE-LAURE LATTION, EDITH HUMMLER, MONIQUE NENNIGER, THIERRY PEDRAZZINI, JEAN-FRANCOIS AUBERT, MARTIN C. MICHEL, MING YANG, GIUSEPPE LEMBO, CARMINE VECCHIONE, MARINA MOSTARDINI, ANDREA SCHMIDT, FRIEDRICH BEERMANN, AND SUSANNA COTECCHIA |
| Title | Decreased blood pressure response in mice deficient of the α1b-adrenergic receptor |
| Journal | Proc. Natl. Acad. Sci. USA |
| Volume | 94 |
| Page | 11589-11594 |
| Year | 1997 |
| PMID | 9326654 |
| Author | Akito Tanoue, Yoshihisa Nasa, Takaaki Koshimizu, Hitomi Shinoura, Sayuri Oshikawa, Takayuki Kawai, Sachie Sunada, Satoshi Takeo, and Gozoh Tsujimoto |
| Title | The α1D-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction |
| Journal | The Journal of Clinical Investigation |
| Volume | 109 |
| Page | 765-775 |
| Year | 2002 |
| PMID | 11901185 |
| Disease name, Applicable field | Physiology |