CARD R-BASE



Mouse strain


Strain information

CARD ID 255
Type of strain Targeted mutant.
Strain name C.129(B6)-Dsg3tm1Stan
Internal Code BALB/c-[Ko]Dsg3 N11, C.129(B6)-DSg3tm1Stan N11
Submitter Shigeo Koyasu
Submitter affiliation or code RIKEN
Stock Type
Material Transfer Conditions Consent to us
Production method From other organizations
Origin (In-house) Organization
Organization code
Developer
Origin (From other organizations) Organization University of Pennsylvania
Organization code Stan
Developer John R. Stanley
Year introduced 1999 / 5
Introduced Generation N0
Remarks


Gene information

Gene symbol Dsg3
Gene name desmoglein 3
Allele symbol
Allele name
MGI MGI:99499,
Chromosome 18 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method
GO Gene Ontology
OMIM OMIM ID: 169615 Human Gene Symbol: DSG3,

PCR Primer 1
primerA Sequence of primers used in reaction
primer name(amplify Neo gene: 280bp)
M11:5'-CTTgggTggAgAggCTATTCggCT
M12:5'-AggTgAgATgACAggAgATCCTgCCC
primerB (amplify Dsg3 gene include intron:442bp)
M13:5'-ATgACCTgCCTCTTCCCTAgAgCCTT
M14:5'-AggCATgCAgAgTTCTTAgCTATATT


References

Author Peter J. Koch, My G. Mahoney, Hiroyasu Ishikawa, Leena Pulkkinen, Jouni Uitto, Leonard Shultz, George F. Murphy, Diana Whitaker-Menezes, and John R. Stanley
Title Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris
Journal The Journal of Cell Biology
Volume 137
Page 1091-1102
Year 1997
PMID 9166409


Disease , Applicable field information

Disease name, Applicable field Dermatology, Development






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