CARD R-BASE



Mouse strain


Strain information

CARD ID 365
Type of strain Targeted mutant.
Strain name B6;129X1-Adra1btm1
Internal Code B6/129sv-α1BD-AR-KO
Submitter Nakamura Kazuaki
Submitter affiliation or code National Research Institute for Child Health and Development
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization
Organization code unknown
Developer Tanoue Akito
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Adra1b
Gene name Adrenergic receptor, alpha 1b
Allele symbol Adra1btm1
Allele name Adra1b, targeted mutation 1
MGI MGI:104774,
Chromosome 11 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
GO Gene Ontology
OMIM OMIM ID: 104220 Human Gene Symbol: ADRA1B,

PCR Primer 1
primerA 2.C alpha1D: (1)PCR primer A 5'(ACACA,GCTGC,ACTCA,GTAGC,AGGTC,A)3'
alpha1B: (1)PCR primer A 5'(CCTGC,AGGTA,TGAGG,CTCTG,T)3'
primerB 2.C alpha1D: (2)PCR primer B 5'(CCTAC,ATTTT,GAATG,GAAGG,ATTG)3'
alpha1B: (2)PCR primer B 5'(ATTTG,TCACG,TCCTG,CACGA,C)3'


References

Author ANTONELLA CAVALLI, ANNE-LAURE LATTION, EDITH HUMMLER, MONIQUE NENNIGER, THIERRY PEDRAZZINI, JEAN-FRANCOIS AUBERT, MARTIN C. MICHEL, MING YANG, GIUSEPPE LEMBO, CARMINE VECCHIONE, MARINA MOSTARDINI, ANDREA SCHMIDT, FRIEDRICH BEERMANN, AND SUSANNA COTECCHIA
Title Decreased blood pressure response in mice deficient of the α1b-adrenergic receptor
Journal Proc. Natl. Acad. Sci. USA
Volume 94
Page 11589-11594
Year 1997
PMID 9326654
Author Akito Tanoue, Yoshihisa Nasa, Takaaki Koshimizu, Hitomi Shinoura, Sayuri Oshikawa, Takayuki Kawai, Sachie Sunada, Satoshi Takeo, and Gozoh Tsujimoto
Title The α1D-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction
Journal The Journal of Clinical Investigation
Volume 109
Page 765-775
Year 2002
PMID 11901185


Disease , Applicable field information

Disease name, Applicable field Physiology






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