CARD ID | 538 | |
Type of strain | Targeted mutant. | |
Strain name | D2.129-Chrm5tm1 | |
Internal Code | 5ND, D2.129-Chrm5tm1 | |
Submitter | Unknown Unknown | |
Submitter affiliation or code | ||
Stock Type | ||
Material Transfer Conditions |
Others
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Production method | in-house breeding | |
Origin (In-house) | Organization | Graduate Sch. Pharm. Sci., Univ. Toyko |
Organization code | ||
Developer | MATSUI Minoru | |
Origin (From other organizations) | Organization | |
Organization code | ||
Developer | ||
Year introduced | ||
Introduced Generation | ||
Remarks |
Gene symbol | Chrm5 |
Gene name | cholinergic receptor, muscarinic 5 |
Allele symbol | Chrm5tm1 |
Allele name | targeted mutation 1 |
MGI | MGI:109248, |
Chromosome | 2 (58.0 cM) , |
Gene classification | Targeted or trapped gene(knockout etc.) |
Method | Electroporation |
GO | Gene Ontology |
OMIM | OMIM ID: 118496 Human Gene Symbol: CHRM5, |
MR18 | 5'-ggggttgatggtgctgttga-3' |
MF23 | 5'-ccctcggactgaaaacaatg-3' |
Author | Takeshi Nakamura, Minoru Matsui, Keiko Uchida, Akira Futatsugi, Shinji Kusakawa, Nagisa Matsumoto, Kyoko Nakamura, Toshiya Manabe, Makoto M. Taketo and Katsuhiko Mikoshiba |
Title | M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice |
Journal | J Physiol |
Volume | 558 |
Page | 561-575 |
Year | 2004 |
PMID | 15146045 |
Author | Takako Ohno-Shosaku, Minoru Matsui, Yuko Fukudome, Jumpei Shosaku, Hiroshi Tsubokawa, Makoto M. Taketo, Toshiya Manabe and Masanobu Kano |
Title | Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus |
Journal | European Journal of Neuroscience |
Volume | 18 |
Page | 109-116 |
Year | 2003 |
PMID | 12859343 |
Author | Minoru Matsui, Daisuke Motomura, Toru Fujikawa, Jian Jiang, Shin-ichi Takahashi, Toshiya Manabe, and Makoto M. Taketo |
Title | Mice Lacking M2 and M3 Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable |
Journal | The Journal of Neuroscience |
Volume | 22 |
Page | 10627-10632 |
Year | 2002 |
PMID | 12486155 |
Author | Minoru Matsui, Daisuke Motomura, Hiroshi Karasawa, Toru Fujikawa, Jian Jiang, Yuriko Komiya, Shin-ichi Takahashi, and Makoto M. Taketo |
Title | Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype |
Journal | PNAS |
Volume | 97 |
Page | 9579-9584 |
Year | 2000 |
PMID | 10944224 |
Author | Hiroshi Karasawa, Makoto M. Taketo, Minoru Matsui |
Title | Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4 |
Journal | European Journal of Pharmacology |
Volume | 468 |
Page | 15-19 |
Year | 2003 |
PMID | 12729838 |
Disease name, Applicable field | Physiology, Anatomy, Immunology, cancer, Dermatology, Neurobiology, Metabolism |