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CARD Mouse Bank


Mouse strain


Strain information

CARD ID 1585
Type of strain Targeted mutant.
Strain name B6;129-Tnnt2tm2Mmto
Internal Code B6;129-Tnnt2tm2Mmto
Submitter Morimoto Sachio
Submitter affiliation or code -
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Kyushu University
Organization code 不明
Developer Sachio Morimoto
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Tnnt2
Gene name troponin T2, cardiac
Allele symbol
Allele name
MGI MGI:104597,
Chromosome 1 (60.0) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM OMIM ID: 601494 Human Gene Symbol: CMD1D,

PCR Primer 1
TNT F2 5'CCT AAG CCC CAG ACC TAT GC
TNT R2 5' GGT TCC TCC CCG TCC C


References

Author Wang et al.
Title Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.
Journal Cardiovasc. Res.
Volume 87(4)
Page 636-646
Year 2010
PMID
Author Zhan et al.
Title Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation.
Journal Cardiovasc. Res.
Volume 84(1)
Page 64-71
Year 2009
PMID
Author Sfichi-Duke et al.
Title Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins.
Journal J. Mol. Cell. Cardiol.
Volume 48(5)
Page 934-942
Year 2010
PMID
Author Du et al.
Title Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation.
Journal Circ. Res.
Volume 101(2)
Page 185-194
Year 2007
PMID


Disease , Applicable field information

Disease name, Applicable field Physiology, Hematology






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