CARD R-BASE



Mouse strain


Strain information

CARD ID 408
Type of strain Targeted mutant.
Strain name B6.129P2-Olr1tm1Saw
Internal Code B6-Lox-1 KO, B6.129P2-Olr1tm1Saw
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization
Organization code
Developer
Origin (From other organizations) Organization National Cardiovascular Center
Organization code
Developer Tatsuya Sawamura (present address: Department of Molecular Pathophysiology, Shinshu University School of Medicine)
Year introduced 1999 / 4
Introduced Generation N2
Remarks


Gene information

Gene symbol Olr1(Chr6, synonym: LOX-1)
Gene name lectin-like oxidized low density lipoprotein receptor-1
Allele symbol
Allele name
MGI MGI:,
Chromosome
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM OMIM ID: 602601



References

Author Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.
Title Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Journal Bone
Volume 75
Page 170-182
Year 2015
PMID 25744064
Author Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T.
Title High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice.
Journal Lipids in Health and Disease
Volume 14
Page 6
Year 2015
PMID 25888871
Author Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M.
Title Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis.
Journal Scandinavian Journal of Rheumatology
Volume 45
Page 412-422
Year 2016
PMID 26901593
Author Mehta, J.L., Sanada, N., Hu, C.P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P.L., Thomas, M. and Sawamura, T.
Title Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.
Journal Circulation Research
Volume 100
Page 1634-1642
Year 2007
PMID 17478727
Author Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.
Title Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
Journal Blood
Volume 127
Page 1336-1345
Year 2016
PMID 26679863


Disease , Applicable field information

Disease name, Applicable field Osteosis, Hematology, Metabolism, Physiology






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