CARD R-BASE



Mouse strain


Strain information

CARD ID 405
Type of strain Targeted mutant.
Strain name B6;129Sv-Irf2tm1Ifnar1tm1
Internal Code B6, B6;129Sv-Irf2tm1Ifnar1tm1
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Consent to us
Production method Both
Origin (In-house) Organization
Organization code
Developer
Origin (From other organizations) Organization
Organization code
Developer
Year introduced 1997
Introduced Generation
Remarks (IRF-2(+/-), IFNAR1(-/-))


Gene information

Gene symbol Ifnar1
Gene name interferon (alpha and beta) receptor 1
Allele symbol Ifnar1tm1
Allele name Ifnar1, targeted mutation 1
MGI MGI:107658,
Chromosome 16 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method
GO Gene Ontology
OMIM OMIM ID: 107450 Human Gene Symbol: IFNAR1,
Gene symbol Irf2
Gene name interferon regulatory-2
Allele symbol Irf2tm1sup
Allele name Irf2, targeted mutation 1
MGI MGI:96591,
Chromosome 8 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method
GO Gene Ontology
OMIM OMIM ID: 147576 Human Gene Symbol: IRF2,

PCR Primer 1
primerA Irf2 F2A4: cgg tag act ctg aag gcg ttg tt
Irf2 F2S3: ttc cag atc ccc tgg atg cat gc
Irf2 F2N : aac gca cgg gtg ttg ggt cgt ttg
Ifnar1 Ifnar1 S: aag atg tgc tgt tcc ctt cct ctg ctc tga
Ifnar1 AS: att att aaa aga aaa gac gag gcg aag tgg
Ifnar1 neo: cct gcg tgc aat cca ctc tg
primerB Irf2 F2A4: cgg tag act ctg aag gcg ttg tt
Irf2 F2S3: ttc cag atc ccc tgg atg cat gc
Irf2 F2N : aac gca cgg gtg ttg ggt cgt ttg
Ifnar1 Ifnar1 S: aag atg tgc tgt tcc ctt cct ctg ctc tga
Ifnar1 AS: att att aaa aga aaa gac gag gcg aag tgg
Ifnar1 neo: cct gcg tgc aat cca ctc tg


References

Author Toshifumi Matsuyama, Tohru Kimura, Motoo Kitagawa, Klaus Pfeffer, Takatoshi Kawakami, Nobumasa Watanabe, Thomas M. Kundig, Ryuichi Amakawa, Kenji Kishihara, Andrew Wakeham, Julia Potter, Caren L. Furlonger, Arumugavadivel Narendran, Haruhiko Suzuki, Pamela S. Ohashi, Christopher J. Paige, Tadatsugu Taniguchi, and Tak W. Mak
Title Targeted Disruption of IRF-1 or IRF-2 Results in Abnormal Type I IFN Gene Induction and Aberrant Lymphocyte Development
Journal Cell
Volume 75
Page 83-97
Year 1993
PMID 8402903
Author Ulrike Muller, Ulrich Steinhoff, Luiz F. L. Reis, Silvio Hemmi, Jovan Pavlovic, Rolf M. Zinkernagel, Michel Aguet
Title Functional Role of Type I and Type II Interferons in Antiviral Defense
Journal SCIENCE
Volume 264
Page 1918-1921
Year 1994
PMID 8009221


Disease , Applicable field information

Disease name, Applicable field Immunology






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