CARD R-BASE



Mouse strain


Strain information

CARD ID 3290
Type of strain Transgenic., Targeted mutant.
Strain name C57BL/6-Dis3em1
Internal Code Dis3-flox mice
Submitter Hiroto Ohguchi
Submitter affiliation or code Division of Disease Epigenetics Institute of Resource Development and Analysis Kumamoto University
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Division of Disease Epigenetics, Institute of Resource Development and Analysis, Kumamoto University
Organization code
Developer Hiroto Ohguchi
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol LoxP
Gene name LoxP
Allele symbol
Allele name
MGI MGI:,
Chromosome
Gene classification Gene to express(transgenic)
Method MicroInjection
OMIM
Gene symbol Dis3
Gene name DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Allele symbol Dis3em1
Allele name DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; endonuclease-mediated mutation 1,
MGI MGI:1919912,
Chromosome
Gene classification Targeted or trapped gene(knockout etc.)
Method
OMIM

PCR Primer 1
Primer1 FW 5'-CTGTCAGTTATAGTAACTCCGCGC-3'
Primer2 RV 5'-GTTGGAGAGCAGAGAGCTGTGAT-3'


References

Author Hiroto Ohguchi, Yasuyo Ohguchi, Sho Kubota, Kan Etoh, Ai Hamashima, Shingo Usuki, Takako Yokomizo-Nakano, Jie Bai, Takeshi Masuda, Yawara Kawano, Takeshi Harada, Mitsuyoshi Nakao, Takashi Minami, Teru Hideshima, Kimi Araki, Goro Sashida
Title Multiple myeloma–associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis
Journal Blood Neoplasia
Volume 1
Page 100005
Year 2024
PMID


Disease , Applicable field information

Disease name, Applicable field cancer, Development, Molecular biology






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