CARD ID | 2104 | |
Type of strain | Transgenic., Targeted mutant. | |
Strain name | B6;129-Pccatm1ToruTg(SAP-Pcca)47Toru | |
Internal Code | PCCA KO/ PCCA TG | |
Submitter | Miyazaki Toru | |
Submitter affiliation or code | Lab of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine (CDBIM), The University of Tokyo | |
Stock Type | ||
Material Transfer Conditions |
Consent to us
|
|
Production method | in-house breeding | |
Origin (In-house) | Organization | |
Organization code | ||
Developer | ||
Origin (From other organizations) | Organization | |
Organization code | ||
Developer | ||
Year introduced | ||
Introduced Generation | ||
Remarks |
Gene symbol | Pcca |
Gene name | propionyl-Coenzyme A carboxylase, alpha polypeptide |
Allele symbol | tg(SAP-Pcca) |
Allele name | |
MGI | MGI:97499, |
Chromosome | |
Gene classification | Gene to express(transgenic) |
Method | MicroInjection |
OMIM |
Gene symbol | Pcca |
Gene name | propionyl-Coenzyme A carboxylase, alpha polypeptide |
Allele symbol | Pccatm1Timy |
Allele name | propionyl-Coenzyme A carboxylase, alpha polypeptide, targeted mutation 1, Toru Miyazaki |
MGI | MGI:97499, |
Chromosome | 14 (65.99) (14E5) , |
Gene classification | Targeted or trapped gene(knockout etc.) |
Method | Electroporation |
OMIM |
beta-globin 5 | TGC TGG TTA TTG TGC TGT CTC ATC |
PCCA 300R | AAT GGC AAC TGT CTT GAT GCC CAT |
RV13 | GTA TCC ATC ATG GCT GAT GCA A |
RV14 | AAC GCT ATG TCC TGA TAG CGG T |
Author | Miyazaki T, Ohura T, Kobayashi M, Shigematsu Y, Yamaguchi S, Suzuki Y, Hata I, Aoki Y, Yang X, Minjares C, Haruta I, Uto H, Ito Y, Müller U |
Title | Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase and its rescue by postnatal, liver-specific supplementation via a transgene. |
Journal | J Biol Chem |
Volume | 276 |
Page | 35995-9 |
Year | 2001 |
PMID |
Disease name, Applicable field | Metabolism |