CARD R-BASE



Mouse strain


Strain information

CARD ID 2091
Type of strain Targeted mutant.
Strain name B6;129-Rab8atm1Rab8btm1
Internal Code Rab8ab DKO
Submitter - -
Submitter affiliation or code -
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization
Organization code
Developer
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks Rab8a+/-; Rab8b-/-


Gene information

Gene symbol Rab8b
Gene name Rab8b, member RAS oncogene
Allele symbol Rab8btm1
Allele name Rab8b, member RAS oncogene, targeted mutation 1
MGI MGI:2442982,
Chromosome 9 (36.17) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM
Gene symbol Rab8a
Gene name Rab8a, member RAS oncogene
Allele symbol Rab8atm1
Allele name Rab8a, member RAS oncogene, targeted mutation 1
MGI MGI:96960,
Chromosome 8 (34.84) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM

PCR Primer 1
8a genotype E tgg ctt atg gca tat ctg ctg g
8a genotype A aag cag gcc tca act cac tga gat c
PCR Primer 2
8a genotype E tgg ctt atg gca tat ctg ctg g
8a genotype R gcc aag ttt ggg gca tag tta c
PCR Primer 3
8bWT-S gtt gga cat ctc ttc acc tat gc
8bNull-AS cag agc ctg aga agg tgc aat g


References

Author Takashi Sato, Tomohiko Iwano, Masataka Kunii, Shinji Matsuda, Rumiko Mizuguchi, Yongwook Jung, Haruo Hagiwara, Yoshihiro Yoshihara, Michisuke Yuzaki, Reiko Harada and Akihiro Harada
Title Rab8a and Rab8b are essential for multiple apical transport pathways but insufficient for ciliogenesis
Journal Journal of Cell Science
Volume
Page
Year in press
PMID
Author Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A.
Title The Rab8 GTPase regulates apical protein localization in intestinal cells.
Journal Nature
Volume 448
Page 366-369
Year 2007
PMID


Disease , Applicable field information

Disease name, Applicable field Physiology, Anatomy, Cell biology, Neurobiology, Metabolism, Digestive Disorders






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