| CARD ID | 583 | |
| Type of strain | Targeted mutant. | |
| Strain name | NZW;129(ICR)(C)-Parp1tm1Hsmm/Hsmm | |
| Internal Code | , NZW;129(ICR)(C)-Parp1tm1Hsmm/Hsmm | |
| Submitter | Unknown Unknown | |
| Submitter affiliation or code | ||
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
|
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| Production method | in-house breeding | |
| Origin (In-house) | Organization | Chugai Pharmaceutical Co. Ltd., National Cancer Center Research Institute |
| Organization code | Csk, Ncc | |
| Developer | Hiroshi Suzuki, Mitsuko Masutani | |
| Origin (From other organizations) | Organization | |
| Organization code | ||
| Developer | ||
| Year introduced | ||
| Introduced Generation | ||
| Remarks | ||
| Gene symbol | Parp1 |
| Gene name | Poly (ADP-ribose) polymerase family, member 1 |
| Allele symbol | Parp1tm1Hsmm |
| Allele name | Parp1,National Cancer Center Research Institute |
| MGI | MGI:1340806, |
| Chromosome | 1 (98.6) , |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | Electroporation |
| OMIM | OMIM ID: 173870 Human Gene Symbol: PARP1, |
| mp66S | 5'-aaa ccg aca cgt tag cgg ag-3' |
| mp23A | 5'-ctt ggg aat act ctc gct gc-3' |
| Author | Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani |
| Title | Parp-1 deficiency causes an increase of deletion mutations and insertions/ rearrangements in vivo after treatment with an alkylating agent |
| Journal | Oncogene |
| Volume | 24 |
| Page | 1328-1337 |
| Year | 2005 |
| PMID | 15608683 |
| Author | MITSUKO MASUTANI, HIROSHI SUZUKI, NOBUO KAMADA, MIHO WATANABE, OTOYA UEDA, TADASHIGE NOZAKI, KOU-ICHI JISHAGE, TAKESHI WATANABE, TETSURO SUGIMOTO, HITOSHI NAKAGAMA, TAKAHIRO OCHIYA, AND TAKASHI SUGIMURA |
| Title | Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes |
| Journal | Proc. Natl. Acad. Sci. USA |
| Volume | 96 |
| Page | 2301-2304 |
| Year | 1999 |
| PMID | 10051636 |
| Author | T. Nohmi, M. Katoh, H. Suzuki, M. Matsui, M. Yamada, M. Watanabe, M. Suzuki, N. Horiya, O. Ueda, T. Shibuya, H. Ikeda, and T. Sofuni |
| Title | A NewTransgenic Mouse Mutagenesis Test System Using Spi- and 6-Thioguanine Selections |
| Journal | Environmental and Molecular Mutagenesis |
| Volume | 28 |
| Page | 465-470 |
| Year | 1996 |
| PMID | 8991079 |
| Disease name, Applicable field | Metabolism, Neurobiology, cancer, Immunology, Physiology |