CARD ID | 3159 | |
Type of strain | Targeted mutant. | |
Strain name | C57BL/6-Cthtm1, Mpsttm1 | |
Internal Code | C57BL/6-Cth(tm1)/Mpst(tm1) | |
Submitter | ISHII ISAO | |
Submitter affiliation or code | Showa Pharmaceutical University | |
Stock Type | ||
Material Transfer Conditions |
Consent to us
|
|
Production method | in-house breeding | |
Origin (In-house) | Organization | Showa Pharmaceutical University |
Organization code | ||
Developer | Isao Ishii | |
Origin (From other organizations) | Organization | |
Organization code | ||
Developer | ||
Year introduced | ||
Introduced Generation | ||
Remarks |
Gene symbol | Cth |
Gene name | cystathionase (cystathionine gamma-lyase) |
Allele symbol | Cthtm1 |
Allele name | cystathionase (cystathionine gamma-lyase); targeted mutation 1, |
MGI | MGI:1339968, |
Chromosome | |
Gene classification | Targeted or trapped gene(knockout etc.) |
Method | Electroporation |
OMIM |
Gene symbol | Mpst |
Gene name | Mercaptopyruvate sulfurtransferase |
Allele symbol | Mpsttm1 |
Allele name | Mercaptopyruvate sulfurtransferase; targeted mutation 1, |
MGI | MGI:2179733, |
Chromosome | |
Gene classification | Targeted or trapped gene(knockout etc.) |
Method | Electroporation |
OMIM |
CSE-F2 | TGCCGACCAATAAGCAGGGC |
CSE-PCR-2 | CCAGACCGGCAACGAAAATCA |
MPST-3 | GCATATAAGGCCAGCACACG |
MPST-7 | AGCTGGGCTACATCTTAGAGA |
Author | Isao Ishii, Noriyuki Akahoshi, Hidenori Yamada, Shintaro Nakano, Takashi Izumi, and Makoto Suematsu |
Title | Cystathionine gamma-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury |
Journal | J. Biol. Chem. |
Volume | 285 |
Page | 26358-26368 |
Year | 2010 |
PMID |
Author | Akahoshi, N., Minakawa, T., Miyashita, M., Sugiyama, U., Saito, C., Takemoto, R., Honda, A., Kamichatani, W., Kamata, S., Anan, Y., Ishii, I. |
Title | Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria. |
Journal | Int J Mol Sci |
Volume | 21 |
Page | 818; doi:10.3390/ijms21030818 |
Year | 2020 Jan 27 |
PMID |
Disease name, Applicable field | Hematology, Digestive Disorders, Metabolism, Diabetes, Physiology |