CARD R-BASE



Mouse strain


Strain information

CARD ID 2362
Type of strain Targeted mutant.
Strain name C3H/HeJ-Cbstm1Unc
Internal Code C3H/HeJ-Cbs-knockout
Submitter ISHII ISAO
Submitter affiliation or code Showa Pharmaceutical University
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Showa Pharmaceutical University
Organization code
Developer Isao Ishii
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Cbs
Gene name cystathionine beta-synthase
Allele symbol Cbstm1Unc
Allele name cystathionine beta-synthase, targeted mutation 1
MGI MGI:88285,
Chromosome 17 (16.93) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method MicroInjection
OMIM

PCR Primer 1
CBS-KO-1 (Common) CGGATGACCTGCATTCATCT
CBS-KO-2 (WT specific) GAAGTGGAGCTATCAGAGCA
CBS-KO-3 (KO specific) GAGGTCGACGGTATCGATA


References

Author Nakano, S., Ishii, I., Shinmura, K., Tamaki, K., Hishiki, T., Akahoshi, N., Ida, T., Nakanishi, T., Kamata, S., Kumagai, Y., Akaike, T., Fukuda, K., Sano, M., Suematsu, M.
Title Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.
Journal J Mol Med (Berl)
Volume 93
Page 879-889
Year 2015
PMID
Author Morikawa, T., Kajimura, M., Nakamura, T., Hishiki, T., Nakanishi, T., Yukutake, Y., Nagahata, Y., Ishikawa, M., Hattori, K., Takenouchi, T., Takahashi, T., Ishii, I., Matsubara, K., Kabe, Y., Uchiyama, S., Nagata, E., Gadalla, M.M., Snyder, S.H., Suematsu, M.
Title Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.
Journal Proc Natl Acad Sci USA
Volume 109
Page 1293-1298
Year 2012
PMID
Author Akahoshi, N., Kobayashi, C., Ishizaki, Y., Izumi, T., Himi, T., Suematsu, M., Ishii, I.
Title Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.
Journal Hum Mol Genet
Volume 17
Page 1994-2005
Year 2008
PMID


Disease , Applicable field information

Disease name, Applicable field Physiology, Behavior, Pharmacology, Development, Dermatology, Neurobiology, Metabolism, Digestive Disorders, Hematology, Osteosis






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