CARD R-BASE



Mouse strain


Strain information

CARD ID 871
Type of strain Targeted mutant.
Strain name B6;129-Wnk4tm1(D561A)
Internal Code Wnk4(D561A) knock-in mouse
Submitter - -
Submitter affiliation or code -
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Tokyo Medical & Dental Univ.
Organization code none
Developer Uchida Shinichi
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Wnk4
Gene name WNK lysine deficient protein kinase 4
Allele symbol
Allele name
MGI MGI:1917097,
Chromosome 11 (syntenic) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
GO Gene Ontology
OMIM OMIM ID: 601844 Human Gene Symbol: WNK4,

PCR Primer 1
SA-end-WNK4- 5'-AGGCCTCGAACTCAGAGACTG-3'
LA1-1R-seg-WNK4- 5'-TGCTGCACCAAGCATAAAGCA-3'


References

Author Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S.
Title Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
Journal Cell Metab.
Volume 5
Page 331-44
Year 2007
PMID


Disease , Applicable field information

Disease name, Applicable field Physiology, Metabolism






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