CARD ID | 2097 | |
Type of strain | Targeted mutant. | |
Strain name | B6;129-Deddtm1TimyDedd2tm1Timy | |
Internal Code | DEDD1+/-DEDD2+/- | |
Submitter | Miyazaki Toru | |
Submitter affiliation or code | Lab of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine (CDBIM), The University of Tokyo | |
Stock Type | ||
Material Transfer Conditions |
Consent to us
|
|
Production method | in-house breeding | |
Origin (In-house) | Organization | The University of Tokyo |
Organization code | ||
Developer | Toru Miyazaki | |
Origin (From other organizations) | Organization | |
Organization code | ||
Developer | ||
Year introduced | ||
Introduced Generation | ||
Remarks |
Gene symbol | Dedd2 |
Gene name | death effector domain-containing DNA binding protein 2 |
Allele symbol | Dedd2tm1Timy |
Allele name | death effector domain-containing DNA binding protein 2, targeted mutation 1, Toru Miyazaki |
MGI | MGI:1914629, |
Chromosome | 7 (13.73) (7A3) , |
Gene classification | Targeted or trapped gene(knockout etc.) |
Method | Electroporation |
OMIM |
Gene symbol | Dedd |
Gene name | death effector domain-containing |
Allele symbol | Deddtm1Timy |
Allele name | death effector domain-containing, targeted mutation 1, Toru Miyazaki |
MGI | MGI:1333874, |
Chromosome | 1 (79.34) (1H2) , |
Gene classification | Targeted or trapped gene(knockout etc.) |
Method | Electroporation |
OMIM |
D5-1 | ATG GCG GGC CTA AAG AGG CGG GCA |
D3-1 | CTC GTC TCT TCT TGA GAG TAA CGT |
TM-1 | CAG CCA GAT TTA CAT AGT GAA ATC |
NY-5 | CCG CTA TCA GGA CAT AGC GTT GGC |
DEDD2 EX1-5 | GAG TGT TTG GAT TAC TAC GGC ATG |
DEDD2 EX1-3 | AGC AAG GTG TTT CTG CAA CTT CCT |
DEDD2 K-B.R9736R | GCC CAG GTC CCT GTA ATA GCA CTT |
TK-inside | TCG ACA TTG GGT GGA AAC ATT CCA |
Author | Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T |
Title | Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. |
Journal | J Clin Invest |
Volume | 121 |
Page | 318-27 |
Year | 2011 |
PMID |
Author | Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K, Nishijima A, Odawara N, Harada S, Nakashima K, Arai S, Miyazaki T |
Title | The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. |
Journal | Biochem Biophys Res Commun |
Volume | 39 |
Page | 1708-13 |
Year | 2009 |
PMID |
Author | Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T. |
Title | The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. |
Journal | J Biol Chem |
Volume | 284 |
Page | 5050-5 |
Year | 2009 |
PMID |
Author | Arai S, Miyake K, Voit R, Nemoto S, Wakeland EK, Grummt I, Miyazaki T |
Title | Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. |
Journal | Proc Natl Acad Sci U S A. |
Volume | 104 |
Page | 2289-94 |
Year | 2007 |
PMID |
Disease name, Applicable field | cancer, Metabolism, Reproduction |