| CARD ID | 405 | |
| Type of strain | Targeted mutant. | |
| Strain name | B6;129Sv-Irf2tm1Ifnar1tm1 | |
| Internal Code | B6, B6;129Sv-Irf2tm1Ifnar1tm1 | |
| Submitter | Unknown Unknown | |
| Submitter affiliation or code | ||
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
|
|
| Production method | Both | |
| Origin (In-house) | Organization | |
| Organization code | ||
| Developer | ||
| Origin (From other organizations) | Organization | |
| Organization code | ||
| Developer | ||
| Year introduced | 1997 | |
| Introduced Generation | ||
| Remarks | (IRF-2(+/-), IFNAR1(-/-)) | |
| Gene symbol | Ifnar1 |
| Gene name | interferon (alpha and beta) receptor 1 |
| Allele symbol | Ifnar1tm1 |
| Allele name | Ifnar1, targeted mutation 1 |
| MGI | MGI:107658, |
| Chromosome | 16 , |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | |
| GO | Gene Ontology |
| OMIM | OMIM ID: 107450 Human Gene Symbol: IFNAR1, |
| Gene symbol | Irf2 |
| Gene name | interferon regulatory-2 |
| Allele symbol | Irf2tm1sup |
| Allele name | Irf2, targeted mutation 1 |
| MGI | MGI:96591, |
| Chromosome | 8 , |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | |
| GO | Gene Ontology |
| OMIM | OMIM ID: 147576 Human Gene Symbol: IRF2, |
| primerA | Irf2 F2A4: cgg tag act ctg aag gcg ttg tt Irf2 F2S3: ttc cag atc ccc tgg atg cat gc Irf2 F2N : aac gca cgg gtg ttg ggt cgt ttg Ifnar1 Ifnar1 S: aag atg tgc tgt tcc ctt cct ctg ctc tga Ifnar1 AS: att att aaa aga aaa gac gag gcg aag tgg Ifnar1 neo: cct gcg tgc aat cca ctc tg |
| primerB | Irf2 F2A4: cgg tag act ctg aag gcg ttg tt Irf2 F2S3: ttc cag atc ccc tgg atg cat gc Irf2 F2N : aac gca cgg gtg ttg ggt cgt ttg Ifnar1 Ifnar1 S: aag atg tgc tgt tcc ctt cct ctg ctc tga Ifnar1 AS: att att aaa aga aaa gac gag gcg aag tgg Ifnar1 neo: cct gcg tgc aat cca ctc tg |
| Author | Toshifumi Matsuyama, Tohru Kimura, Motoo Kitagawa, Klaus Pfeffer, Takatoshi Kawakami, Nobumasa Watanabe, Thomas M. Kundig, Ryuichi Amakawa, Kenji Kishihara, Andrew Wakeham, Julia Potter, Caren L. Furlonger, Arumugavadivel Narendran, Haruhiko Suzuki, Pamela S. Ohashi, Christopher J. Paige, Tadatsugu Taniguchi, and Tak W. Mak |
| Title | Targeted Disruption of IRF-1 or IRF-2 Results in Abnormal Type I IFN Gene Induction and Aberrant Lymphocyte Development |
| Journal | Cell |
| Volume | 75 |
| Page | 83-97 |
| Year | 1993 |
| PMID | 8402903 |
| Author | Ulrike Muller, Ulrich Steinhoff, Luiz F. L. Reis, Silvio Hemmi, Jovan Pavlovic, Rolf M. Zinkernagel, Michel Aguet |
| Title | Functional Role of Type I and Type II Interferons in Antiviral Defense |
| Journal | SCIENCE |
| Volume | 264 |
| Page | 1918-1921 |
| Year | 1994 |
| PMID | 8009221 |
| Disease name, Applicable field | Immunology |