CARD R-BASE



Mouse strain


Strain information

CARD ID 2095
Type of strain Targeted mutant.
Strain name B6;129-Deddtm1Timy
Internal Code DEDD KO
Submitter Miyazaki Toru
Submitter affiliation or code Lab of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine (CDBIM), The University of Tokyo
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization The University of Tokyo
Organization code
Developer Toru Miyazaki
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Dedd
Gene name death effector domain-containing
Allele symbol Deddtm1Timy
Allele name death effector domain-containing, targeted mutation 1, Toru Miyazaki
MGI MGI:1333874,
Chromosome 1 (79.34) (1H2) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM

PCR Primer 1
D5-1 ATG GCG GGC CTA AAG AGG CGG GCA
D3-1 CTC GTC TCT TCT TGA GAG TAA CGT
PCR Primer 2
TM-1 CAG CCA GAT TTA CAT AGT GAA ATC
NY-5 CCG CTA TCA GGA CAT AGC GTT GGC


References

Author Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T
Title Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice.
Journal J Clin Invest
Volume 121
Page 318-27
Year 2011
PMID
Author Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K, Nishijima A, Odawara N, Harada S, Nakashima K, Arai S, Miyazaki T
Title The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.
Journal Biochem Biophys Res Commun
Volume 39
Page 1708-13
Year 2009
PMID
Author Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T.
Title The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.
Journal J Biol Chem
Volume 284
Page 5050-5
Year 2009
PMID
Author Arai S, Miyake K, Voit R, Nemoto S, Wakeland EK, Grummt I, Miyazaki T
Title Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
Journal Proc Natl Acad Sci U S A.
Volume 104
Page 2289-94
Year 2007
PMID


Disease , Applicable field information

Disease name, Applicable field Molecular biology, Cell biology, cancer, Reproduction






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