CARD R-BASE



Mouse strain


Strain information

CARD ID 589
Type of strain Targeted mutant.
Strain name ICR;129S4-Pargtm2Ncc/Csk
Internal Code , ICR;129S4-Pargtm2Ncc/Csk
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Chugai Research Institute for Medical Science Inc., National Cancer Center Research Institute
Organization code Csk, Ncc
Developer Kou-ichi Jishage, Mitsuko Masutani
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Parg
Gene name Poly (ADP-ribose) glycohydrolase
Allele symbol Pargtm2Ncc
Allele name Parg,National Cancer Center Research Institute
MGI MGI:1347094,
Chromosome 14 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM OMIM ID: 603501 Human Gene Symbol: PARG,



References

Author Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani
Title Parp-1 deficiency causes an increase of deletion mutations and insertions/ rearrangements in vivo after treatment with an alkylating agent
Journal Oncogene
Volume 24
Page 1328-1337
Year 2005
PMID 15608683
Author MITSUKO MASUTANI, HIROSHI SUZUKI, NOBUO KAMADA, MIHO WATANABE, OTOYA UEDA, TADASHIGE NOZAKI, KOU-ICHI JISHAGE, TAKESHI WATANABE, TETSURO SUGIMOTO, HITOSHI NAKAGAMA, TAKAHIRO OCHIYA, AND TAKASHI SUGIMURA
Title Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
Journal Proc. Natl. Acad. Sci. USA
Volume 96
Page 2301-2304
Year 1999
PMID 10051636


Disease , Applicable field information

Disease name, Applicable field Metabolism, Development






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