CARD R-BASE



Mouse strain


Strain information

CARD ID 293
Type of strain Targeted mutant.
Strain name B6;129-Mdktm1
Internal Code MK knockout mouse, MK knockout mouse (C57BL6J/129SV)
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Department of Biochemistry, Nagoya University, Graduate School of Medicine
Organization code
Developer Takashi Muramatsu
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Mdk
Gene name Midkine
Allele symbol Mdktm1
Allele name Mdk, targeted mutation 1
MGI MGI:96949,
Chromosome 2 (53.0cM) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method
GO Gene Ontology
OMIM OMIM ID: 162096 Human Gene Symbol: MDK,

PCR Primer 1
primerA 5'(TAACC,CAggT,TTTAC,CCCTA)3'
primerB 5'(CTCCA,AATTC,CTTCC,TTCTT,CCAg)3'


References

Author Mitsuru Horiba, Kenji Kadomatsu, Eishin Nakamura, Hisako Muramatsu, Shinya Ikematsu, Sadatoshi Sakuma, Kenji Hayashi, Yukio Yuzawa, Seiichi Matsuo, Masafumi Kuzuya, Tadashi Kaname, Makoto Hirai, Hidehiko Saito, and Takashi Muramatsu
Title Neointima formation in a restenosis model is suppressed in midkine-deficient mice
Journal The Journal of Clinical Investigation
Volume 105
Page 489-495
Year 2000
PMID 10683378
Author Eishin Nakamura, Kenji Kadomatsu, Shigeki Yuasa, Hisako Muramatsu, Takayoshi Mamiya, Toshitaka Nabeshima, Qi-Wen Fan, Kazuhiro Ishiguro, Tadahiko Igakura, Shuichiro Matsubara, Tadashi Kaname, Mitsuru Horiba, Hidehiko Saito and Takashi Muramatsu
Title Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour
Journal Genes to Cells
Volume 3
Page 811-822
Year 1998
PMID 10096022
Author Waichi Sato, Kenji Kadomatsu, Yukio Yuzawa, Hisako Muramatsu, Nigishi Hotta, Seiichi Matsuo, and Takashi Muramatsu
Title Midkine Is Involved in Neutrophil Infiltration into the Tubulointerstitium in Ischemic Renal Injury
Journal The Journal of Immunology
Volume 167
Page 3463-3469
Year 2001
PMID 11544339


Disease , Applicable field information

Disease name, Applicable field Development






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