CARD R-BASE



Mouse strain


Strain information

CARD ID 1851
Type of strain Targeted mutant.
Strain name B6-Rpt3tm1
Internal Code floxed Rpt3
Submitter Takahashi Ryosuke
Submitter affiliation or code Department of Neurology kyoto University Graduate School of Medicine
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Department of Neurology kyoto University Graduate School of Medicine
Organization code
Developer Yoshitaka Tashiro , Ryousuke Takahashi
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Psmc4
Gene name proteasome (prosome, macropain) 26S subunit, ATPase, 4
Allele symbol Psmc4tm1
Allele name targeted mutation 1
MGI
Chromosome 7 (16.11) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method MicroInjection
OMIM

PCR Primer 1
floxed-Rpt3-F TGAGCTGTGTATCAAGGTCC
floxed-Rpt3-R TAGAAGCTGCCTAAGGCACA


References

Author Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R.
Title Motor Neuron-specific Disruption of Proteasomes, but not Autophagy, Replicates Amyotrophic Lateral Sclerosis.
Journal J Biol Chem.
Volume
Page PMID: 23095749
Year 2012
PMID


Disease , Applicable field information

Disease name, Applicable field Respiratory System, Aging, Behavior, Molecular biology, Development, Laboratory-animal Science, Cell biology, Genetics, Immunology, Obesity, Diabetes, infectious, cancer, Urology, peromelia, Dermatology, Neurobiology, Endocrine Disorders, Metabolism, Reproduction, Digestive Disorders, Hematology, Otorhinology, Dentistry, Osteosis, Ophthalomology






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