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CARD Mouse Bank


Mouse strain


Strain information

CARD ID 541
Type of strain Targeted mutant.
Strain name B6.129-Chrm5tm1
Internal Code 5NJ, B6.129-Chrm5tm1
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Others
Production method in-house breeding
Origin (In-house) Organization 東京大学薬学部
Organization code
Developer MATSUI Minoru
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Chrm5
Gene name cholinergic receptor, muscarinic 5
Allele symbol Chrm5tm1
Allele name targeted mutation 1
MGI MGI:109248,
Chromosome 2 (58.0 cM) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
GO Gene Ontology
OMIM OMIM ID: 118496 Human Gene Symbol: CHRM5,



References

Author Hiroshi Karasawa, Makoto M. Taketo, Minoru Matsui
Title Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4
Journal European Journal of Pharmacology
Volume 468
Page 15-19
Year 2003
PMID 12729838
Author Minoru Matsui, Daisuke Motomura, Hiroshi Karasawa, Toru Fujikawa, Jian Jiang, Yuriko Komiya, Shin-ichi Takahashi, and Makoto M. Taketo
Title Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype
Journal PNAS
Volume 97
Page 9579-9584
Year 2000
PMID 10944224
Author Minoru Matsui, Daisuke Motomura, Toru Fujikawa, Jian Jiang, Shin-ichi Takahashi, Toshiya Manabe, and Makoto M. Taketo
Title Mice Lacking M2 and M3 Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable
Journal The Journal of Neuroscience
Volume 22
Page 10627-10632
Year 2002
PMID 12486155
Author Takako Ohno-Shosaku, Minoru Matsui, Yuko Fukudome, Jumpei Shosaku, Hiroshi Tsubokawa, Makoto M. Taketo, Toshiya Manabe and Masanobu Kano
Title Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus
Journal European Journal of Neuroscience
Volume 18
Page 109-116
Year 2003
PMID 12859343
Author Takeshi Nakamura, Minoru Matsui, Keiko Uchida, Akira Futatsugi, Shinji Kusakawa, Nagisa Matsumoto, Kyoko Nakamura, Toshiya Manabe, Makoto M. Taketo and Katsuhiko Mikoshiba
Title M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice
Journal J Physiol
Volume 558
Page 561-575
Year 2004
PMID 15146045


Disease , Applicable field information

Disease name, Applicable field Metabolism, Neurobiology, Dermatology, cancer, Immunology, Development, Anatomy, Physiology






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