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CARD Mouse Bank


Mouse strain


Strain information

CARD ID 404
Type of strain Targeted mutant.
Strain name B6;129Sv-Irf2tm1Prkrtm1
Internal Code B6, B6;129Sv-Irf2tm1Prkrtm1
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Consent to us
Production method From other organizations
Origin (In-house) Organization
Organization code
Developer
Origin (From other organizations) Organization
Organization code
Developer
Year introduced 1997
Introduced Generation
Remarks


Gene information

Gene symbol Prkr
Gene name protein kinase, interferon-inducible double stranded RNA dependent
Allele symbol Prkrtm1
Allele name Prkr, targeted mutation 1
MGI MGI:1353449,
Chromosome 17 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method
GO Gene Ontology
OMIM OMIM ID: 176871 Human Gene Symbol: EIF2AK2,
Gene symbol Irf2
Gene name interferon regulatory factor-2
Allele symbol Irf2tm1
Allele name Irf2, targeted mutation 1
MGI MGI:96591,
Chromosome 8 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method
GO Gene Ontology
OMIM OMIM ID: 147576 Human Gene Symbol: IRF2,

PCR Primer 1
primerA Irf2 F2A4: cgg tag act ctg aag gcg ttg tt
Irf2 F2S3: ttc cag atc ccc tgg atg cat gc
Irf2 F2N: aac gca cgg gtg ttg ggt cgt ttg
PKR-S common: ttt taa agc aga tgg tcc agg ag
PKR as WT: ctg agg cac act cag cct ttt at
PKR neo: att cgc agc gca tcg cct tct at
primerB Irf2 F2A4: cgg tag act ctg aag gcg ttg tt
Irf2 F2S3: ttc cag atc ccc tgg atg cat gc
Irf2 F2N: aac gca cgg gtg ttg ggt cgt ttg
PKR-S common: ttt taa agc aga tgg tcc agg ag
PKR as WT: ctg agg cac act cag cct ttt at
PKR neo: att cgc agc gca tcg cct tct at


References

Author Toshifumi Matsuyama, Tohru Kimura, Motoo Kitagawa, Klaus Pfeffer, Takatoshi Kawakami, Nobumasa Watanabe, Thomas M. Kundig, Ryuichi Amakawa, Kenji Kishihara, Andrew Wakeham, Julia Potter, Caren L. Furlonger, Arumugavadivel Narendran, Haruhiko Suzuki, Pamela S. Ohashi, Christopher J. Paige, Tadatsugu Taniguchi, and Tak W. Mak
Title Targeted Disruption of IRF-1 or IRF-2 Results in Abnormal Type I IFN Gene Induction and Aberrant Lymphocyte Development
Journal Cell
Volume 75
Page 83-97
Year 1993
PMID 8402903
Author Terada, K., Ueno, S., Yomogida, K., Imai, T., Kiyonari, H., Takeda, N., Yano, M., Abe, S., Aizawa, S., & Mori, M.
Title Expression of Tom34 splicing isoforms in mouse testis and knockout of Tom34 in mice.
Journal J. Biochem.
Volume 133
Page 625-631
Year 2003
PMID 12801914


Disease , Applicable field information

Disease name, Applicable field Immunology






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