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CARD Mouse Bank


Mouse strain


Strain information

CARD ID 399
Type of strain Targeted mutant.
Strain name B6;129-Irf3tm1Isgf3gtm1
Internal Code IRF-3 KO, IRF-9 KO, B6;129-Irf3tm1Isgf3gtm1
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Department of Immunology, Graduate School of Medicine, The University of Tokyo
Organization code
Developer Tadatsugu Taniguchi
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Irf3
Gene name interferon regulatory factor 3
Allele symbol Irf3tm1
Allele name Irf3, targeted mutation 1
MGI MGI:1859179,
Chromosome 7 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
GO Gene Ontology
OMIM OMIM ID: 603734 Human Gene Symbol: IRF3,
Gene symbol Isgf3g (synonym:Irf-9)
Gene name interferon dependent positive acting transcription factor 3 gamma
Allele symbol Isgf3gtm1
Allele name Isgf3g, targeted mutation 1
MGI MGI:107587,
Chromosome 14 ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
GO Gene Ontology
OMIM OMIM ID: 147574 Human Gene Symbol: IRF9,

PCR Primer 1
primerA IRF3 common: gaa cct cgg agt tat ccc gaa gg
IRF3 d.s: gtt tga gtt atc cct gca ctt ggg
Neo pri: tcg tgc ttt acg cta tcg ccg ctc ccg att

ISGF3g: tca atg ttc cga tgt ggc agt tca aag gat c
E3g: tat cga ata ctg cca gca gga acc c
Neo p48: tc
primerB


References

Author Tohru Kimura, Yuzo Kadokawa, Hisashi Harada, Masahito Matsumoto, Mitsuharu Sato, Yasuo Kashiwazaki, Masahito Tarutani, Rosemary Sok-Pin Tan, Tomohiro Takasugi, Toshifumi Matsuyama, Tak W. Mak, Shigeru Noguchi and Tadatsugu Taniguchi
Title Essential and non-redundant roles of p48 (ISGF3γ)and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies
Journal Genes to Cells
Volume 1
Page 115-124
Year 1996
PMID 9078371
Author Mitsuharu Sato, Hirofumi Suemori, Naoki Hata, Masataka Asagiri, Kouetsu Ogasawara, Kazuki Nakao, Takeo Nakaya, Motoya Katsuki, Shigeru Noguchi, Nobuyuki Tanaka, and Tadatsugu Taniguchi
Title Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
Journal Immunity
Volume 13
Page 539-548
Year 2000
PMID 11070172


Disease , Applicable field information

Disease name, Applicable field Immunology






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