| CARD ID | 2095 | |
| Type of strain | Targeted mutant. | |
| Strain name | B6;129-Deddtm1Timy | |
| Internal Code | DEDD KO | |
| Submitter | Miyazaki Toru | |
| Submitter affiliation or code | Lab of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine (CDBIM), The University of Tokyo | |
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
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| Production method | in-house breeding | |
| Origin (In-house) | Organization | The University of Tokyo |
| Organization code | ||
| Developer | Toru Miyazaki | |
| Origin (From other organizations) | Organization | |
| Organization code | ||
| Developer | ||
| Year introduced | ||
| Introduced Generation | ||
| Remarks | ||
| Gene symbol | Dedd |
| Gene name | death effector domain-containing |
| Allele symbol | Deddtm1Timy |
| Allele name | death effector domain-containing, targeted mutation 1, Toru Miyazaki |
| MGI | MGI:1333874, |
| Chromosome | 1 (79.34) (1H2) , |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | Electroporation |
| OMIM |
| D5-1 | ATG GCG GGC CTA AAG AGG CGG GCA |
| D3-1 | CTC GTC TCT TCT TGA GAG TAA CGT |
| TM-1 | CAG CCA GAT TTA CAT AGT GAA ATC |
| NY-5 | CCG CTA TCA GGA CAT AGC GTT GGC |
| Author | Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T |
| Title | Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. |
| Journal | J Clin Invest |
| Volume | 121 |
| Page | 318-27 |
| Year | 2011 |
| PMID |
| Author | Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K, Nishijima A, Odawara N, Harada S, Nakashima K, Arai S, Miyazaki T |
| Title | The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. |
| Journal | Biochem Biophys Res Commun |
| Volume | 39 |
| Page | 1708-13 |
| Year | 2009 |
| PMID |
| Author | Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T. |
| Title | The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. |
| Journal | J Biol Chem |
| Volume | 284 |
| Page | 5050-5 |
| Year | 2009 |
| PMID |
| Author | Arai S, Miyake K, Voit R, Nemoto S, Wakeland EK, Grummt I, Miyazaki T |
| Title | Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. |
| Journal | Proc Natl Acad Sci U S A. |
| Volume | 104 |
| Page | 2289-94 |
| Year | 2007 |
| PMID |
| Disease name, Applicable field | Molecular biology, Cell biology, cancer, Reproduction |