CARD R-BASE



Mouse strain


Strain information

CARD ID 580
Type of strain Targeted mutant.
Strain name B6.129(ICR)-Parp1tm1Hsmm/Hsmm
Internal Code , B6.129(ICR)-Parp1tm1Hsmm/Hsmm
Submitter Unknown Unknown
Submitter affiliation or code
Stock Type
Material Transfer Conditions Consent to us
Production method in-house breeding
Origin (In-house) Organization Chugai Pharmacetical Co. Ltd., National Cancer Center Reasearch Institute
Organization code Csk, Ncc
Developer Hiroshi Suzuki, Mitsuko Masutani
Origin (From other organizations) Organization
Organization code
Developer
Year introduced
Introduced Generation
Remarks


Gene information

Gene symbol Parp1
Gene name Poly (ADP-ribose) polymerase family, member 1
Allele symbol Parp1tm1Hsmm
Allele name Parp1,National Cancer Center Research Institute
MGI MGI:1340806,
Chromosome 1 (98.6) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation
OMIM OMIM ID: 173870 Human Gene Symbol: PARP1,

PCR Primer 1
neo628A 5'-cgc caa tga caa gac gct ggg cgg g-3'
mp137A 5'-c gcc cgc tct tcg cgt act gca c-3'


References

Author Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani
Title Parp-1 deficiency causes an increase of deletion mutations and insertions/ rearrangements in vivo after treatment with an alkylating agent
Journal Oncogene
Volume 24
Page 1328-1337
Year 2005
PMID 15608683
Author MITSUKO MASUTANI, HIROSHI SUZUKI, NOBUO KAMADA, MIHO WATANABE, OTOYA UEDA, TADASHIGE NOZAKI, KOU-ICHI JISHAGE, TAKESHI WATANABE, TETSURO SUGIMOTO, HITOSHI NAKAGAMA, TAKAHIRO OCHIYA, AND TAKASHI SUGIMURA
Title Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
Journal Proc. Natl. Acad. Sci. USA
Volume 96
Page 2301-2304
Year 1999
PMID 10051636
Author T. Nohmi, M. Katoh, H. Suzuki, M. Matsui, M. Yamada, M. Watanabe, M. Suzuki, N. Horiya, O. Ueda, T. Shibuya, H. Ikeda, and T. Sofuni
Title A NewTransgenic Mouse Mutagenesis Test System Using Spi- and 6-Thioguanine Selections
Journal Environmental and Molecular Mutagenesis
Volume 28
Page 465-470
Year 1996
PMID 8991079


Disease , Applicable field information

Disease name, Applicable field Metabolism, Neurobiology, cancer, Immunology, Physiology






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