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CARD Mouse Bank

Mouse strain

Strain information

CARD ID 2253
Type of strain Targeted mutant.
Strain name C57BL/6-Choptm1
Internal Code Chop KO
Submitter Oike Yuich
Submitter affiliation or code -
Stock Type
Material Transfer Conditions Consent to us
Production method From other organizations
Origin (In-house) Organization
Organization code
Origin (From other organizations) Organization Osaka University
Organization code
Developer Shizuo Akira
Year introduced 2000 / 4
Introduced Generation 20

Gene information

Gene symbol Ddit3
Gene name DNA-damage inducible transcript 3
Allele symbol Ddit3tm1
Allele name DNA-damage inducible transcript 3, targeted mutation 1,
MGI MGI:109247,
Chromosome 10 (74.50) (10 D3) ,
Gene classification Targeted or trapped gene(knockout etc.)
Method Electroporation

PCR Primer 1
sCHOP1 cctggattaagcttggtagt
aCHOP5 ggacgcagggtcaagagtag
neo-F agaggctattcggctatgac
neo-R gcttgccgaatatcatggtg


Author Y. Miyazaki, K. Kaikita, M. Endo, E. Horio, M. Miura, K. Tsujita, S. Hokimoto, M. Yamamoto, T. Iwawaki, T. Gotoh, H. Ogawa & Y. Oike.
Title C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation.
Journal Arterioscler. Thromb. Vasc. Biol.,
Volume 31
Page 1124-1132
Year 2011
Author H. Tsukano, T. Gotoh*, M. Endo, K. Miyata, H. Tazume, T. Kadomatsu, M. Yano, T. Iwawaki, K. Kohno, K. Araki, H. Mizuta & Y. Oike.
Title The Endoplasmic Reticulum Stress-CHOP Pathway-mediated Apoptosis in Macrophages Contributes to the Instability of Atherosclerotic Plaques.
Journal Arterioscler. Thromb. Vasc. Biol.,
Volume 30
Page 1925-1932
Year 2010
Author S. Oyadomari, A. Koizumi, K. Takeda, T. Gotoh, S. Akira, E. Araki & M. Mori.
Title A targeted disruption of the CHOP gene protects mice against ER stress-induced diabetes.
Journal J. Clin. Invest.
Volume 109
Page 525-532
Year 2002

Disease , Applicable field information

Disease name, Applicable field Cell biology, Diabetes, infectious, Neurobiology, Metabolism, Hematology

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