| CARD ID | 408 | |
| Type of strain | Targeted mutant. | |
| Strain name | B6.129P2-Olr1tm1Saw | |
| Internal Code | B6-Lox-1 KO, B6.129P2-Olr1tm1Saw | |
| Submitter | Unknown Unknown | |
| Submitter affiliation or code | ||
| Stock Type | ||
| Material Transfer Conditions |
Consent to us
|
|
| Production method | in-house breeding | |
| Origin (In-house) | Organization | |
| Organization code | ||
| Developer | ||
| Origin (From other organizations) | Organization | National Cardiovascular Center |
| Organization code | ||
| Developer | Tatsuya Sawamura (present address: Department of Molecular Pathophysiology, Shinshu University School of Medicine) | |
| Year introduced | 1999 / 4 | |
| Introduced Generation | N2 | |
| Remarks | ||
| Gene symbol | Olr1(Chr6, synonym: LOX-1) |
| Gene name | lectin-like oxidized low density lipoprotein receptor-1 |
| Allele symbol | |
| Allele name | |
| MGI | MGI:, |
| Chromosome | |
| Gene classification | Targeted or trapped gene(knockout etc.) |
| Method | Electroporation |
| OMIM | OMIM ID: 602601 |
| Author | Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y. |
| Title | Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state. |
| Journal | Bone |
| Volume | 75 |
| Page | 170-182 |
| Year | 2015 |
| PMID | 25744064 |
| Author | Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T. |
| Title | High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice. |
| Journal | Lipids in Health and Disease |
| Volume | 14 |
| Page | 6 |
| Year | 2015 |
| PMID | 25888871 |
| Author | Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M. |
| Title | Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis. |
| Journal | Scandinavian Journal of Rheumatology |
| Volume | 45 |
| Page | 412-422 |
| Year | 2016 |
| PMID | 26901593 |
| Author | Mehta, J.L., Sanada, N., Hu, C.P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P.L., Thomas, M. and Sawamura, T. |
| Title | Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. |
| Journal | Circulation Research |
| Volume | 100 |
| Page | 1634-1642 |
| Year | 2007 |
| PMID | 17478727 |
| Author | Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H. |
| Title | Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. |
| Journal | Blood |
| Volume | 127 |
| Page | 1336-1345 |
| Year | 2016 |
| PMID | 26679863 |
| Disease name, Applicable field | Osteosis, Hematology, Metabolism, Physiology |